Research explores cell receptors for bat viruses to understand the emergence of zoonotic diseases

New research shows that the bat virus’s closest relatives of the human Middle East Respiratory Syndrome (MERS) coronavirus efficiently bind to bat ACE2 receptors as an entry point into these cells. These receptors have some similarities to the ACE2 receptors on human cells. However, at present this coronavirus, called NeoCoV, and a similar virus, PDF-2180, …

Read More…

Scientists Develop New Receptor “Decoy” Drug That Potently Neutralizes SARS-CoV-2 Variants

Scientists at the Dana-Farber Cancer Institute have developed a drug that potently neutralizes SARS-CoV-2, the COVID-19 coronavirus, and is equally effective against the Omicron variant and any other variant tested. The drug is designed in such a way that natural selection to maintain the infectivity of the virus should also maintain the drug’s activity against …

Read More…

Researchers explore the correlation between the dynamic pattern of SARS-CoV-2 clearance and viral load

In a recent article published in Nature Reviews Microbiologythe researchers sought to establish an association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load, indicating its ribonucleic acid (RNA) levels, and the presence of infectious virions. Study: SARS-CoV-2 viral load and clearance kinetics. Image Credit: CROCODILE/Shutterstock In addition, they examined the host and other …

Read More…

Researchers develop a polyvalent lipid nanoparticle mRNA vaccine against monkeypox virus

In a recent study published in the bioRxiv*server, investigators developed a messenger ribonucleic acid (mRNA) technology-based vaccine candidate against monkeypox virus (MPXV) and evaluated its immunogenicity in animal models. Study: Vaccination with polyvalent mRNA elicited a potent immune response to monkeypox surface antigens. Image Credit: Wachiwit/Shuterstock Background The mRNA vaccines, mRNA-1273 and BNT162b2, achieved unexpectedly …

Read More…

Study sheds light on origins of Omicron virus, Health News, ET HealthWorld

Berlin (Germany): The SARS-CoV-2 subtype, later named “Omicron”, was discovered a year ago in South Africa and rapidly spread throughout the world. It is still unknown how, when or where this virus developed. Researchers from Charite – Universitatsmedizin Berlin and a network of African institutions have published a study in the journal Science* showing that …

Read More…

Gargling with povidone-iodine may reduce salivary viral load in patients with COVID-19

A prospective, randomized, open-label clinical trial demonstrates that povidone-iodine gargling accelerates viral shedding and reduces salivary infectivity in patients with asymptomatic or mild coronavirus disease 2019 (COVID-19). The trial findings have been published in the journal scientific reports. Study: A prospective, randomized, open-label trial of early versus delayed povidone-iodine gargling in patients with COVID-19. Image …

Read More…

Broadly Cross-Reactive Antibodies Protecting From SARS-CoV-2 Variants Revealed by Virus Cold Spot-Driven Discovery

A recent study published in bioRxiv*Identified neutralizing antibodies (nAbs) against conserved epitopes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Human neutralizing antibodies against cold linear epitopes and against subdomain 1 of SARS-CoV-2. Image Credit: Yurchanka Siarhei/Shutterstock Background Most nAbs against SARS-CoV-2 target the N-terminal (NTD) and receptor-binding (RBD) domains of the spike protein. …

Read More…

The Antibody Resistance Profile and Viral Receptor Binding Affinity of SARS-CoV-2 Subvariants BQ.1, BQ.1.1, XBB, and XBB.1 Omicron

In a recent study published in the bioRxiv* Preprint server, investigators investigated neutralizing antibody titers against Omicron subvariants BQ.1, BQ.1.1, XBB, and XBB.1 recently emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using sera from individuals with primary and booster vaccinations against coronavirus disease 2019 (COVID-19) and previous SARS-CoV-2 infections. Study: Alarming antibody evasion properties …

Read More…

Small CDC study looks at viral shedding of SARS-CoV-2 in vaccinated and unvaccinated people

The risk of transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be assessed by determining the time course of dissemination using diagnostic indicators such as cycle threshold (Ct) values ​​through recovery of SARS-CoV-2 from viral culture. and reverse transcriptase polymerase chain reaction (RT-PCR) tests. Based on previous studies, RT-PCR results remained positive for …

Read More…