2022 Week 1 College Football Odds, Picks & Predictions – Tested Computer Model Backing Florida, Louisville

College football is king in the sports world over Labor Day weekend, and the Week 1 schedule doesn’t disappoint in 2022. The headliner is No. 2 Ohio State vs. No. 5 Notre Dame on Saturday night. But there are plenty of other matchups to look forward to, including No. 3 Georgia vs. No. 11 Oregon, No. 7 Utah vs. Florida and No. 19 Arkansas vs. No. 23 Cincinnati.

The latest Week 1 college football odds from Caesars Sportsbook list the Buckeyes as 17.5-point favorites over the Fighting Irish. The Bulldogs are -17, the Utes are -3, and the Razorbacks are -6. Whether you’re looking to place a bet on one of those Week 1 college football spreads or any other over the long weekend, there’s plenty to consider. Before you lock in any Week 1 college football picks, be sure to check out the latest college football predictions from SportsLine’s advanced computer model.

The SportsLine projection model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated an impressive profit of nearly $3,600 for $100 players on their top-rated college football picks against the spread. He enters Week 1 of the 2022 college football season riding a 45-32 streak in all of the top-rated college football money line and spread picks going back to 2021. Anyone who has followed him has seen large profits.

Now, he’s turned his attention to the latest Caesars Week 1 college football odds and has locked down picks for every FBS matchup. Head here to see each choice.

Best College Football Predictions for Week 1

One of the college picks the model figures prominently in Week 1: Florida (+3) covers at home against No. 7 Utah at 7 p.m. ET on Saturday. The Gators are led by a standout quarterback in Anthony Richardson, who is a top prospect in the NFL. First-year head coach Billy Napier brought several key pieces of his offense from Louisiana, and he will have a solid offensive line.

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The Gators also have an excellent running game, giving them the pieces to be effective immediately against Utah. There will be a large crowd available for a night game in The Swamp, making life difficult for visiting Utes in a cross-country travel spot. SportsLine’s model expects Richardson to record more than 320 total yards, which is one reason the Gators cover the spread nearly 60% of the time.

Another prediction: Louisville hits the streets and is easily covered as a 4-point favorite against Syracuse in a matchup at 8 pm ET on Saturday. The Cardinals went 6-6 in the regular season last year before losing their bowl game against the Air Force. But they do return a lot of talent on offense, led by quarterback Malik Cunningham. They also added transfer running back Tiyon Evans, who was effective in his first season at Tennessee in 2021.

Meanwhile, Syracuse went 5-7 last year and finished the season on a three-game winning streak. That stretch included a 41-3 blowout loss to Louisville. Orange will bring in a new starting quarterback after losing Tommy DeVito on the transfer portal. SportsLine’s model calls for about 250 passing yards and two touchdowns for Cunningham, who also has 76 rushing yards. Louisville covers more than 60% of the time, while Under (56.5) reaches nearly 60% of the time. See what other outfits the model likes here.

How to make college football picks for week 1

The model has also made the call on who wins and covers in all other FBS matchups in Week 1, and is calling out a heavy favorite to go down hard in a shocking upset. She can only get each pick for each game on SportsLine.

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So what college football picks can you make with confidence? And which big favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams are winning and making up the spread, all from a proven computer model that has generated nearly $3,600 in profits over the past six seasons and find out.

College Football Odds for Week 1 (via Caesars)

See the full Week 1 college football picks, odds and predictions here

Thursday, September 1

Ball State at Tennessee (-35, 68)

West Virginia at Pittsburgh (-7.5, 52)

featured game | Pittsburgh Panthers vs. West Virginia Mountaineers

Penn State at Purdue (+3.5, 53.5)

featured game | Purdue Boilermakers vs. Penn State Nittany Lions

Friday, September 2

Illinois at Indiana (-3, 45.5)

featured game | Indiana Hoosiers vs. Illinois Fighting Illini

TCUs at Colorado (+13.5, 55.5)

featured game | Colorado Buffaloes vs. TCU Horned Frogs

Saturday, September 3

Colorado State at Michigan (-27.5, 58.5)

featured game | Michigan Wolverines vs. Colorado State Rams

Cincinnati at Arkansas (-6, 51.5)

featured game | Arkansas Razorbacks vs. Cincinnati Bearcats

Oregon at Georgia (-17.5, 52)

featured game | Georgia Bulldogs vs. Oregon Ducks

UTEP at Oklahoma (-31.5, 57)

Rice at USC (-33.5, 61.5)

Utah at Florida (+3, 51)

featured game | Florida Gators vs. Utah Utes

Utah State at Alabama (-41.5, 62.5)

Notre Dame at Ohio State (-17.5, 58.5)

featured game | Ohio State Buckeyes vs. Notre Dame Fighting Irish

Sunday, September 4

Florida State at LSU (-3, 51.5)

featured game | LSU Tigers vs. Florida State Seminoles

Monday, September 5

Clemson at Georgia Tech (+21.5, 49)

featured game | Georgia Tech Yellow Jackets vs. Clemson Tigers

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